I tend toward furry, techie, and manga, but there's a little of everything here!
(and the bloody list keeps getting longer!)
It's Walky!/Roomies - It's over, but there's 7 years of archives! One of the best Webcomics ever - HIGHLY recommended!
User Friendly the Comic Strip
PvPonline.com - The Daily Online Comic
General Protection Fault--The Comic Strip
The Wandering Ones
The Class Managerie (No longer being updated - it's over :(
FANS! is over, too, but the full archives are available at Graphic Smash (subscription required.)
Cyantia Chronicles (actually several comics in the same continuum, updated on a rotating schedule)
College Roomies From Hell!
The Life of Riley (on hiatus, but it's archived here)
Sluggy Freelance - Is it Not Nifty? One of the longest running (since 1997!) web-comics out there for a reason.
El Goonish Shive Who cares what it means? It's weird (in a good way!)
Black Tapestries - Shapeshifting, magical, immortal fantasy adventure! (Tuesday-Friday, actually)
The Devil's Panties - How could you not like a name like that?
Monday, Wednesday, Friday, and sometimes Saturday!:
...is over, try
Penny Arcade Cartoons
The Suburban Jungle (Starring Tiffany Tiger) ...
The Joy of Tech!
Girl Genius Online - Phil Foglio's dead-tree comic brought to the Wild World Weird!
The Wotch - Witches in training, transformations, weirdness galore!
Shortpacked! - David Willis' new comic about... life working in a toy store?
Zap! - cat girls, psychics, critters, & robots? I'm there!
DMFA - Adventure, wings, succubi, carnivorous cows!
Tuesday and Thursday:
*Okashina Okashi - Strange Candy!*
Whenever the mood strikes:
After Y2K by Nitrozac. The next millennium is...
Framed!!! (or Naught Framed, or whatever Damonk is calling it now...) Might actually update some year...
Goblin Hollow/Under the Lemon Tree
Ghost: 2138 - Sunday - if they ever start updating again...
Snorty - Mini humor every Sunday
SSDD - MF
Zebra Girl - Friday-ish
Eversummer Eve - Monday
Nodwick - D & D humor galore! - Wednesday-ish
Misty The Mouse by Dutch!
Mine's Bigger! - busty, undead elfin humor. Updates Wednesdays.
Keenspot: The Best Damn Comics on the Web
Big Panda Comics
the Evil Network
GameSpy.com - Comics!